RAF Typhoon FGR4s have operated alongside French warplanes in a combined operation on an subterranean weapons facility in Syria operated by the IS group, per a report from the UK's MoD.
The facility, pinpointed through intelligence, was believed to be storing arms and explosives, the announcement noted, and was positioned in mountainous terrain just to the north of the historic site of Palmyra in Syria's central region.
"Our fighter planes employed Paveway IV guided bombs to hit a several access tunnels down to the depot... early reports indicate the objective was successfully hit," the MoD said.
There was no evidence of any civilian impact in the attack late on Saturday and each participating jet returned to base without incident, the MoD added.
The British jets were assisted by a Voyager tanker plane.
Daesh - also known as the so-called Islamic State - enforced extremist governance over large swathes of Syria and Iraq before its territorial defeat in 2019.
"This action shows our UK leadership, and commitment to work closely with our allies, to stamp out any resurgence of Daesh and their harmful and extremist ideologies in the area," Britain's Defence Chief the Defence Secretary remarked.
UK warplanes have conducted overwatch operations over Syria to "prevent any efforts to regroup" of Islamic State following its routing at the climactic battle in Baghuz in 2019, the authorities noted.
"I extend gratitude to every member of the UK armed forces participating in this operation for their professionalism and their valour," the Defence Secretary commented. "They were among thousands of British troops stationed over Christmas and New Year. This action, to remove dangerous terrorists who threaten our safety, shows how British military are prepared to act, continuously, protecting the UK domestically and powerful internationally."
Last December, the American forces executed what it called a "large-scale strike" against IS targets in Syria, following an assault killed two American soldiers and a civilian linguist in Palmyra.
The U.N. says Daesh still boasts an estimated 5,000 to 7,000 combatants in Syria and Iraq.